Artificial light at night: melatonin as a mediator between the environment and epigenome

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Artificial light at night: melatonin as a mediator between the environment and epigenome.

The adverse effects of excessive use of artificial light at night (ALAN) are becoming increasingly evident and associated with several health problems including cancer. Results of epidemiological studies revealed that the increase in breast cancer incidents co-distribute with ALAN worldwide. There is compiling evidence that suggests that melatonin suppression is linked to ALAN-induced cancer ri...

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The mechanisms underpinning the ecological impacts of the presence of artificial night lighting remain elusive. One suspected underlying cause is that the presence of light at night (LAN) supresses nocturnal production of melatonin, a key driver of biological rhythm and a potent antioxidant with a proposed role in immune function. Here, we briefly review the evidence for melatonin as the link b...

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Artificial light at night: a neglected population health concern of the built environment.

Research inquiries of links between the built environment and population health have largely focused onphysical activity and social connectedness, associated health risks or benefits, and resultant chronic diseases; as well as access to healthy food, exposure to green views or green space, blue space, noise abatement, air pollution and biodiversity. Artificial light at night (ALAN) is mentioned...

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Background: Artificial light at night (ALAN) has been linked to increased risk of cancers in body sites like the breast and colorectum. However exposure of ALAN as an environmental risk factor and its relation to cancers in humans has never been studied in detail. Objective: To explore the association of ALAN with all forms of cancers in 158 countries. Materials and Methods: An ecological study...

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ژورنال

عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences

سال: 2015

ISSN: 0962-8436,1471-2970

DOI: 10.1098/rstb.2014.0121